MASTITOMIC
Host – microbiota interactions in the homeostasis of the bovine mammary gland ecosystem: the mastitis model
D.D. del MUR n. 1409 del 14/09/2022
Coordinator: Università degli Studi di Padova, Dipartimento di Agronomia Animali Alimenti Risorse Naturali e Ambiente - DAFNAE
Principal Investigator for Unibo: Martina Zappaterra
Research topics: Animal Science
Duration: 30/11/2023 - 30/11/2025
Research group: Martina Zappaterra, Leonardo Nanni Costa, Barbara Padalino.
Objectives:
Hypothesizing that subclinical mastitis may arise from a dysbiosis in the mammary gland and that some early risk factors may be identified, our aims are i) Characterize the longitudinal evolution of host-microbiota interaction in healthy and affected animals; ii) To assess the role of host genetics, environmental factors, and mammary microbiota in mastitis infection; iii) To implement a data-integration framework aimed at generating predictions about the mastitis risk.
Expected results:
Data will be integrated to model the risk factors associated with the occurrence of subclinical mastitis, providing an unprecedented insight into host-microbiome interaction in healthy and mastitic cows. The joint analysis of all data produced within MASTITOMIC will also allow to evaluate the feasibility of sensor data for the prediction and/or early detection of mastitis infection in dairy cattle. The results will suggest practices for reducing the incidence of mastitis and will produce knowledge relevant to industry stakeholders as well as information transposable to human medicine.
Funding
Funded by the European Union - NextGenerationEU under the National Recovery and Resilience Plan (PNRR) - Mission 4 Education and research - Component 2 From research to business - Investment 1.1 Notice PRIN 2022 PNRR (DD N. 1409 del 14/09/2022), from title "Host – microbiota interactions in the homeostasis of the bovine mammary gland ecosystem: the mastitis model", proposal code P2022C74R9 - CUP J53D23018280001.